How to make an initialism out of a word/phrase with a number?

I have a question. How do I make an initialism out of a word/phrase with a number?

For an example: Should Rainbow 6 Siege be R6S because of initialism is an abbreviation made of initial letters but 6 is not a letter.

Answer

It’s perfectly acceptable to use a ‘numeronym

A numeronym is a word where a number is used to form an abbreviation, such as K9 for canine, or W3 for World Wide Web etc.

https://en.wikipedia.org/wiki/Numeronym

Your reference of Rainbow 6 Siege as R6S is a perfectly acceptable numeronym.

Attribution
Source : Link , Question Author : phwt , Answer Author : GoodJuJu

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